Grant funding: Kenneth Hargreaves, DDS, PhD
Funding Agency: NIH/NINDS (1 R01 NS110948-01A1)
Title: Mechanisms for Omega-6 Modulation of Primary Afferent Nociceptors
Status: Active
Period: 09/18/2019 - 11/30/2024
Role: Principal Investigator
Grant Details: To determine the effects and mechanisms for omega-6 PUFAs on pain and nociceptor sensitization.
Funding Agency: NIH/NCATS (UL1 TR 001120-05)
Title: Clinical and Translational Science Award, CTSA program (includes Mentored Career Development Award KL2 TR001118 and Training Award TL1 TR 001119) Institute for Integration of Medicine & Science: A Partnership to Improve Health Major
Status: Active
Period: 11/01/2018 - 04/30/2023
Role: Co-Principal Investigator (Clark and Hargreaves)
Grant Details: This Clinical and Translational Science Award provides a broad range of research infrastructure support.
Funding Agency: NIH/NIDCR (R01 DE026139)
Title: Regulation of TRPV1 activities by a sexually dimorphic mechanism
Status: Active
Period: 09/01/2016 - 08/31/2021
Role: Principal Investigator
Grant Details: To determine mechanisms regulating the release and actions of C3a and C5a on TRPV1.
Funding Agency: NIH/NIDCR (T32 DE014318-19)
Title: Craniofacial Oral-biology Student Training in Academic Research (COSTAR) (Comprehensive Oral Science Training and Research)
Status: Active
Period: 12/01/2018 – 11/30/2023
Role: Principal Investigator
Grant Details: This is a training grant with tracks in training DDS/PhD students, PhD students and postdoctoral fellows in dental and craniofacial related research.
Funding Agency: American Association of Endodontists Foundation (AAEF)
Title: Regeneration of pulp-dentin development in teeth with necrotic pulps
Status: Active
Period: 12/01/2013 – 11/30/2020
Role: Principal Investigator
Grant Details: This is a multi-center randomized controlled clinical trial evaluating regenerative endodontic therapies to MTA apexification.
Funding Agency: William and Ella Owens Medical Research Foundation
Title: A Novel Approach to Pain Control
Status: Active
Period: 01/01/2018 – 11/31/2020
Role: Principal Investigator
Grant Details: To identify novel ways to treat pain.
Awards: Kenneth Hargreaves, DDS, PhD
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2018 ADA Gold Medal Award for Research.
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2018 Honorary Membership, American Academy of Oral Medicine for “Outstanding contribution to the Art and Science of Oral Medicine
Grant funding: Armen Akopian, PhD
Funding Agency: NIH/NINDS (1 R01 NS112263-01A1)
Title: Lymphotoxin-beta receptor peripheral signaling regulates the transition to inflammation and neuropathy-induced chronic pain.
Status: Active
Period: 05/15/2020 - 03/31/2025
Role: Multi-PI: Akopian and Tumanov
Grant Details: The major goals are to examine roles of Lymphotoxin-beta receptor (LTbR) peripheral signaling in control of inflammatory and neuropathy pain initiation, maintenance and resolution.
Funding Agency: NIH/NIDCR (R01 DE029187)
Title: LIGHT and Lymphotoxin targeting for the treatment of chronic orofacial pain conditions
Period: 09/01/19 - 08/31/24
Role: Multi-PI: Akopian, S. Ruparel and Tumanov
Grant Details: The proposed research major goal is to advance our understanding of mechanisms regulating the development and maintenance of orofacial pain; and offers targets and an immunotherapeutic approach for preventing and blocking chronic pain during TMJD and oral cancer.
Funding Agency: NIH Supplement from NIDCR (3 R01 DE029187-01S1)
Title: Role of LIGHT/LTBR in orofacial pain in non-human primates.
Status: Active
Period: 08/01/2020 - 07/31/2021
Role: Multi-PI: Akopian, Ruparel
Grant Details: The purpose of this grant is to study pain targets in non-human primates
Funding Agency: NIH/NIGMS (Akopian)
Title: Prolactin regulation of postoperative pain in males and females
Period: 09/01/2015 - 08/31/2020 (NCE)
Role: Principal Investigator
Grant Details: The major goals of this project are to identify and characterize female-specific pharmacology of PRL receptor antagonists in regulation of postoperative pain.
Funding Agency: NIH/NIDCR
Title: Regulation of TRPV1 activities by a sexually dimorphic mechanism
Status: Active
Period: 09/01/2016 - 08/31/2021
Role: Co-Investigator (Hargreaves)
Grant Details: The main goal of this project is to examine sex-dependent modulation of tooth pain by compliment C3a and TRPV1.
Funding Agency: NIH/NINDS (5 R01 NS102161)
Title: Sex-specific regulation of local translation and chronic pain mechanisms in females
Status: Active
Period: 04/01/18-03/31/23
Role: Multi-PI: Price and Akopian
Grant Details: The project will look at how gonadal hormones control plasticity phenotypes control chronicity of pain in females by involving local translation and especially prolactin receptor translation.
Funding Agency: NIH/NINDS (R01 NS104200)
Title: Meningeal prolactin signaling and female-selective migraine mechanisms
Status: Active
Period: 09/01/18-08/31/23
Role: Multi-PI: Dussor and Akopian
Grant Details: The major goals of this project are to study the role of meningeal prolactin system in female-selective mechanisms of migraine triggered by vasodilatory hormone CGRP and stress.
Funding Agency: NIH/NIDCR (R01 DE027929)
Title: Trigeminal Afferent Regulation of Apical Periodontitis
Status: Active
Period: 08/01/2018 – 07/31/2023
Role: Co-Investigator (Diogenes)
Grant Details: This grant will evaluate how different trigeminal afferent subtypes modulate the development and maintenance of apical periodontitis.
Grant funding: Anibal Diogenes, DDS, MS, PhD
Funding Agency: NIH/NIDCR (R01 DE027929)
Title: Trigeminal Afferents Regulation of Apical Periodontitis Development
Status: Active
Period: 08/01/2018 – 07/31/2023
Role: Principal Investigator
Grant Details: This grant will evaluate how different trigeminal afferent subtypes modulate the development and maintenance of apical periodontitis following dental infection.
Grant funding: Nikita Ruparel, DDS, MS, PhD
Funding Agency: NIH/NIDCR (1 R03 DE027780)
Title: Endogenous Peripheral Pain Regulatory Systems in Orofacial Pain Patients
Status: Active
Period: 2018 – 2020
Role: Principal Investigator
Grant Details: This grant aims to evaluate mechanisms inhibiting pain in asymptomatic dental pain patients to develop novel analgesics for pain.
Funding Agency: NIH/NIDCR (R01 DE026139)
Title: Regulation of TRPV1 activities by a sexually dimorphic mechanism
Status: Active
Period: 2016 – 2021
Role: Co-Investigator (Hargreaves)
Grant Details: The main goal of this project is to examine sex-dependent modulation of tooth pain by compliment C3a and TRPV1.
Grant funding: Shivani Ruparel, PhD
Funding Agency: NIH/NINDS (R01 DE027223)
Title: Role of Peripheral BDNF Signaling in Oral Cancer Pain
Status: Active
Period: 08/01/2017 – 07/31/2021
Role: Principal Investigator
Grant Details: The purpose of this grant is to elucidate the peripheral role of BDNF in oral cancer pain.
Funding Agency: NIH/NIDCR (R01 DE029187)
Title: LIGHT and Lymphotoxin targeting for the treatment of chronic orofacial pain conditions
Period: 09/01/2019 – 08/31/2024
Role: Multi-PI: Akopian, S. Ruparel and Tumanov
Grant Details: The proposed research major goal is to advance our understanding of mechanisms regulating the development and maintenance of orofacial pain; and offers targets and an immunotherapeutic approach for preventing and blocking chronic pain during TMJD and oral cancer.
Funding Agency: NIH Supplement from NIDCR (3 R01 DE029187-01S1)
Title: Role of LIGHT/LTBR in orofacial pain in non-human primates.
Status: Active
Period: 08/01/2020 – 07/31/2021
Role: Multi-PI: Akopian, Ruparel
Grant Details: The purpose of this grant is to study pain targets in non-human primates
2020 Dominic Arris
- Won 3rd place at Dental Science Symposium 2020 in the PhD/resident category.
- Accepted into the COSTAR grant program in 2020
2019 Shivam Patel (UTHSCSA Dental Student Class of 2022)
Title of research: Endogenous Role of Peripheral Regulating Systems in Orofacial Pain Patients
- Won 1st place at Dental Science Symposium 2020
- Awarded with the AADR Student Research Day Award for the American Association for Dental Research, 2020
- Selected for Hatton award at AADR 2020
2019 Akihiko Osada (UTHSCSA Dental Student Class of 2022)
Title of research: Mechanisms of Stem Cell-induced Analgesia
- Won 1st place at Dental Science Symposium 2020
2018 Saeed Bayat, DDS
Title of research: in vivo Anti-inflammatory Role of Oral Mesenchymal Stem Cells and it’s Soluble factors in Orofacial Inflammatory Pain
- Won 2nd place in the oral presentation category at the annual American Association of Endodontists Meeting 2018
2018 Cameron Ritter, DDS
Title of research: Effect of Residual Biofilm on Release and Activity of Growth Factors from Dentin
- Funded by a grant from the American Association of Endodontists Foundation (PI: Cameron Ritter)
- Won 1st place in the oral presentation category at the annual American Association of Endodontists Meeting 2018
2018 Jenny Sun, DDS
Title of research: Comparative Evaluation of Coronal and Radicular Dentin Growth Factors and their Effect on Mineralization, Angiogenesis and Neurogenesis
Funded by a grant from The American Association of Endodontists Foundation (PI: Jenny Sun)
2018 Obadah Austah, DDS, MS, PhD
Title of research: Role of sensory innervation in modulating the initiation and development of apical periodontitis
Funded by a grant from The American Association of Endodontists Foundation (PI: Obadah Austah)
2018 Shilpa Ganatra, BDS
Laboratory training with trigeminal neuronal cultures, mouse surgeries, biochemical assays, calcium imaging and behavioral assays
- Won 2nd place at Dental Science Symposium 2019
2018 Robert Brock (UTHSCSA Dental Student Class of 2021
Title of research: Mechanisms of Stem Cell-mediated Analgesia
- Won 1st place at Dental Science Symposium 2019
- Awarded with the AADR Student Research Day Award for the American Association for Dental Research, 2019
- Selected for Hatton award at AADR 2019
2017 Samantha Whitten (UTHSCSA Dental Student Class of 2020)
Title of research: in vivo Anti-inflammatory Role of Oral Mesenchymal Stem Cells and it’s Soluble factors in Orofacial Inflammatory Pain
- Won 2nd place in the poster presentation category at the Annual Dental Science Symposium 2018
2017 Thomas Khuong Nguyen (UTHSCSA Dental Student Class of 2019)
Title of research: Immunoregulatory Role of Stem Cells of Apical Papilla (SCAP)
- Funded by a grant from The American Association of Endodontists Foundation (PI: Nikita Ruparel)
- Won 1st place at Dental Science Symposium 2017
- Awarded with the ADA/DENTSPLY Sirona Student Clinician Research Award (SCADA)
- Selected for Hatton award at AADR 2017
- Won 1st place for “Most Outstanding Poster Research Presentation” at The Hinmann Symposium, Tennessee
- He was a finalist in the CAULK-DENTSPLY student research competition at the 2018 American Association for Dental Research annual meeting
2016 Lilley Gharavi, BDS
Title of research: The Expression and Function of Transient Receptor Potential Channels on Stem Cells of Apical Papilla
- Funded by a grant from the American Association of Endodontists Foundation (PI: Lilley Gharavi)
- Won2nd place in the oral presentation category at the annual American Association of Endodontists Meeting 2016
2016 Abdulmajeed M. Al Shujaa, DDS
Title of research: Characterization of Pain-Modulating Substances in Periradicular Lesions from Teeth with Symptomatic and Asymptomatic Periradicular Pathology
Funded by a grant from the American Association of Endodontists Foundation (PI: Abdulmajeed M Al Shujaa)